Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status
نویسندگان
چکیده
منابع مشابه
Hormone Receptor Status And Obesity Affect Risk Of Breast Cancer
First, some words about body shapes. Most men tend to be "apples" in that they carry most of their weight above the waist. Most women, on the other hand, are "pears", carrying more of their weight in the hips and thighs, as shown in the figure above. However, some women are more like apples, and their weight is distributed more like that of men. And if apples and pears become obese, these diffe...
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Folate plays an important role in DNA methylation, and aberrant methylation of the estrogen receptor (ER) gene may be related to the loss of ER gene expression in breast tumors. Thus, deficient folate status has been hypothesized to be associated primarily with ER gene-negative breast tumors, but data relating folate intake to breast cancer risk according to ER status are sparse. We conducted a...
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BACKGROUND Epidemiologic studies of the association between nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, and breast cancer risk have yielded inconsistent results. We investigated the association of NSAID use with risk of breast cancer in the California Teachers Study cohort, with special attention to risk of specific breast cancer subtypes and to type of NSAID u...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2012
ISSN: 0022-2593,1468-6244
DOI: 10.1136/jmedgenet-2011-100716